Detalhe da pesquisa
1.
Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures.
Cell
; 180(4): 655-665.e18, 2020 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32004463
2.
Crystal Structure of the Human Cannabinoid Receptor CB2.
Cell
; 176(3): 459-467.e13, 2019 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-30639103
3.
Crystal Structure of the Human Cannabinoid Receptor CB1.
Cell
; 167(3): 750-762.e14, 2016 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27768894
4.
Synthon-based ligand discovery in virtual libraries of over 11 billion compounds.
Nature
; 601(7893): 452-459, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34912117
5.
1-, 2- and 3-AG as substrates of the endocannabinoid enzymes and endogenous ligands of the cannabinoid receptor 1.
Biochem Biophys Res Commun
; 591: 31-36, 2022 02 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34995983
6.
Oxa-adamantyl cannabinoids.
Bioorg Med Chem Lett
; 38: 127882, 2021 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33636308
7.
Secretion, isotopic labeling and deglycosylation of N-acylethanolamine acid amidase for biophysical studies.
Protein Expr Purif
; 145: 108-117, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29253688
8.
Binding Site Characterization of AM1336, a Novel Covalent Inverse Agonist at Human Cannabinoid 2 Receptor, Using Mass Spectrometric Analysis.
J Proteome Res
; 16(7): 2419-2428, 2017 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28374590
9.
Specific Inter-residue Interactions as Determinants of Human Monoacylglycerol Lipase Catalytic Competency: A ROLE FOR GLOBAL CONFORMATIONAL CHANGES.
J Biol Chem
; 291(6): 2556-65, 2016 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26555264
10.
The role of human monoacylglycerol lipase (hMAGL) binding pocket in breakup of unsaturated phospholipid membranes.
Anal Biochem
; 536: 90-95, 2017 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28822686
11.
Active-site inhibitors modulate the dynamic properties of human monoacylglycerol lipase: a hydrogen exchange mass spectrometry study.
Biochemistry
; 52(29): 5016-26, 2013 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-23795559
12.
Design and Synthesis of Highly Potent and Specific ABHD6 Inhibitors.
ChemMedChem
; 18(21): e202100406, 2023 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34486233
13.
Mass spectrometric characterization of human N-acylethanolamine-hydrolyzing acid amidase.
J Proteome Res
; 11(2): 972-81, 2012 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22040171
14.
Improved cyclobutyl nabilone analogs as potent CB1 receptor agonists.
Eur J Med Chem
; 230: 114027, 2022 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35051750
15.
Mass spectrometry-based proteomics of human cannabinoid receptor 2: covalent cysteine 6.47(257)-ligand interaction affording megagonist receptor activation.
J Proteome Res
; 10(10): 4789-98, 2011 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21861534
16.
Novel Functionalized Cannabinoid Receptor Probes: Development of Exceptionally Potent Agonists.
J Med Chem
; 64(7): 3870-3884, 2021 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33761251
17.
Mass spectrometry-based GPCR proteomics: comprehensive characterization of the human cannabinoid 1 receptor.
J Proteome Res
; 9(4): 1746-53, 2010 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-20131867
18.
Conformational gating, dynamics and allostery in human monoacylglycerol lipase.
Sci Rep
; 10(1): 18531, 2020 10 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33116203
19.
Covalent inhibitors of human monoacylglycerol lipase: ligand-assisted characterization of the catalytic site by mass spectrometry and mutational analysis.
Chem Biol
; 15(8): 854-62, 2008 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-18721756
20.
Biochemical and Proteomic Characterization of Recombinant Human α/ß Hydrolase Domain 6.
Sci Rep
; 9(1): 890, 2019 01 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-30696836